Ecosystem for Startups in the Metropolitan Region Rhine-Neckar | 5-HT Digital Hub Chemistry & Health

Regional ecosystem for startups

Active and lively in the Metropolitan Region Rhine-Neckar.

The startup ecosystem in the Metropolitan Region Rhine-Neckar is active and specialized in the fields of digital health and digital chemistry. In addition to the 5-HT Digital Hub, several other networks, startup centers and accelerators actively support and advise startups and new companies in the region.

Corporate & Investment Partners

In addition to startup support partners and events, companies and investors in the Rhine-Neckar region are also willing to cooperate with startups. Many of the largest German companies from the chemical and life sciences sectors as well as companies from the strong German SME sector are based in the Rhine-Neckar region. Research shows that 62 % of regional startups willing to cooperate work with established companies. Another 16 % of these startups work with strategic investors instead of companies.

Also at 5-HT we can help you connect with your potential future German customers & collaboration partners. For startups in our network, we can organize corporate feedback sessions and other connections with our partners.

Networking events

Founders and young companies need a network. In the Rhine-Neckar region, many events are planned each year where you can network and meet the people who will help your company move forward. Below, you will find an overview of some partners and events in the region per industry.

Life Sciences

  • Life Science Accelerator BW
  • BioRN Lounge
  • BioRN Espresso
  • BioRN Annual Conference

Digital health

  • Inspire program
  • Pilot Incubator
  • Insuring Digital Health

Digital chemistry

  • X-linker


  • Mannheim Conference on Energy and the Environment

Municipal Startup Partner

Several partners of 5-HT offer (free) consultations for startups on a variety of topics related to starting and running your business. These partners are located in the main cities of the region, i.e. Mannheim, Ludwigshafen and Heidelberg.

In addition, local chambers of commerce and industry offer free information and advice on:

  • Legal and tax consultating
  • CE certification
  • Technology transfer and IP
  • Insurances
  • Funding programs

You can find more information about the advisory services offered by the chambers of industry and commerce on their websites: and Here it is also possible to register directly for a consultation event.

Startup partner in Mannheim

At STARTUP MANNHEIM you can get individual advice from several experts on what to consider when setting up a company in the region. An association of partners in Mannheim offers vouchers for a free consultation for certain target groups.

Focus on medical technology

There is a large funding infrastructure in Mannheim especially for startups in the field of medical technology. Programs and centers within this infrastructure include:

If you are interested in getting in touch with the actors in this infrastructure, we encourage you to contact Ms. Katharina Klotzbach directly or contact us at

You can also read our interview here.

Startup partner in Ludwigshafen

The Startup Centers in Ludwigshafen also offer consulting services for young founders:

If you want to learn more about the TZL Technology Center Ludwigshafen, you can read our interview here.

Startup partner in Heidelberg

Heidelberg has several startup centers that support startups in their ventures. The main location is the Technologiepark Heidelberg with several subsidiaries offering a wide range of services.

If you want to learn more about these, you can read our interview here.

Spaces and Co-Working Spaces

Together with our shareholders and cooperation partners, we provide over 100,000 square meters of space, divided into co-working spaces, lab, office and event spaces. If that's what you're looking for, you've come to the right place.

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